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Saturday 30th August 2008 01:29 PM This Month's Genome Publications

Genomics refers to the study of genes and their function. Genomics leads to an understanding of the molecular mechanisms of disease, including the complex interplay of genetic and environmental factors. Genomics is important in the development of drugs, design of new drugs, vaccines and DNA diagnostics. Genomics-based therapeutics include "traditional" small chemical drugs, protein drugs, and gene therapy. Genomics refers to the large-scale investigation of the structure and function of genes. Genomics aids drug discovery and development, agroscience research, and other fields.

Recent Publications by Featured Genomics Companies:

Pubmed Logo
AstraZeneca Pharmaceuticals Imidazole piperazines: SAR and development of a potent class of cyclin-dependent kinase inhibitors with a novel binding mode.
A piperazine series of cyclin-dependent kinase (CDK) inhibitors have been...
Cancer and Infection Research Area, AstraZeneca Pharmaceuticals, Alderley Bioorg Med Chem Lett. 2008 Aug 1;18(15):4442-6. Epub 2008 Jun 12.
DOI Direct Link
AstraZeneca An antibody panel for immunohistochemical analysis of the retina in Davidson's-fixed, paraffin-embedded eyes of rats.
Unlike most other tissues, the optimal fixative for preserving eye...
Department of Pathology, Safety Assessment, AstraZeneca, Alderley Park, Exp Toxicol Pathol. 2008 Aug 19.
DOI Direct Link
GlaxoSmithKline Effect of Dutasteride on Intraprostatic Androgen Levels in Men With Benign Prostatic Hyperplasia or Prostate Cancer.
OBJECTIVES: Dutasteride exerts its beneficial effects on the prostate...
Urology Clinical Development and Medical Affairs, GlaxoSmithKline, Urology. 2008 Aug 19.
DOI Direct Link
GlaxoSmithKline Epidemiology of opioid pharmacy claims in the United States.
OBJECTIVE: To describe opioid pharmacy claims patterns in the United...
Worldwide Epidemiology, GlaxoSmithKline, Research Triangle Park, North J Opioid Manag. 2008 May-Jun;4(3):145-52.
GlaxoSmithKline Pharmaceuticals The identification of potent, selective and CNS penetrant furan-based inhibitors of B-Raf kinase.
Modification of the potent imidazole-based B-Raf inhibitor SB-590885...
Department of Medicinal Chemistry, Neurology and GI Centre of Excellence Bioorg Med Chem Lett. 2008 Aug 1;18(15):4373-6. Epub 2008 Jun 24.
DOI Direct Link
GlaxoSmithKline Effect of Dutasteride on Intraprostatic Androgen Levels in Men With Benign Prostatic Hyperplasia or Prostate Cancer.
OBJECTIVES: Dutasteride exerts its beneficial effects on the prostate...
Urology Clinical Development and Medical Affairs, GlaxoSmithKline, Urology. 2008 Aug 19.
DOI Direct Link
GlaxoSmithKline Epidemiology of opioid pharmacy claims in the United States.
OBJECTIVE: To describe opioid pharmacy claims patterns in the United...
Worldwide Epidemiology, GlaxoSmithKline, Research Triangle Park, North J Opioid Manag. 2008 May-Jun;4(3):145-52.

Patents:

USPTO logo
CompanyUS Patent No.Title
Syngenta 7414183 Inbred corn line G07-NPAF5359
Syngenta 7414178 Soybean cultivar S07-02KG294306
Syngenta 7414175 Soybean cultivar S06-BA046119
Syngenta 7414064 4-(3,3-dihalo-allyloxy) phenoxy alkyl derivatives
Syngenta 7411119 Inbred corn line G07-NP2457
Syngenta 7411116 Inbred corn line G5205
AstraZeneca 7411074 Process and intermediates for the preparation of the thienopyrrole derivatives
AstraZeneca 7411070 Form of S-omeprazole
AstraZeneca 7410972 Compounds
Syngenta 7410967 Pyridodiazines as plant fungicides

Latest Genomics Publications:
Obesity Promotes Left Ventricular Concentric Rather Than Eccentric Geometric Remodeling and Hypertrophy Independent of Blood Pressure.
BackgroundAs it is uncertain whether excess adiposity promotes primarily ...
Woodiwiss AJ, Libhaber CD, Majane OH, Libhaber E, Maseko M, Norton GR,
http://dx.doi.org/10.1038/ajh.2008.252
Am J Hypertens. 2008 Aug 28.
Genomics: when the chemistry is good. n.blow@boston.nature.com. Blow N,
http://dx.doi.org/10.1038/nmeth0908-843
Nat Methods. 2008 Sep;5(9):843-50.
Plant transposable elements.
Genomic programs are yielding tremendous amounts of data about plant ...
Deragon JM, Casacuberta JM, Panaud O,
http://dx.doi.org/10.1159/000126007
Genome Dyn. 2008;4:69-82.
Quantitative proteomic analysis of bean plants infected by a virulent and avirulent obligate rust fungus.
Plants appear to have two types of active defenses, a broad-spectrum basal ...
Lee J, Feng J, Campbell KB, Scheffler BE, Garrett WM, Thibivilliers S, Stacey G, Naiman DQ, Tucker ML, Pastor-Corrales MA, Cooper B,
http://dx.doi.org/10.1074/mcp.M800156-MCP200
Mol Cell Proteomics. 2008 Aug 28.
Race, populations, and genomics: Africa as laboratory.
Much of the recent debate over race, genetics, and health has focused on ...
Braun L, Hammonds E,
http://dx.doi.org/10.1016/j.socscimed.2008.07.018
Soc Sci Med. 2008 Aug 26.
Yeast chemical genomics and drug discovery: an update.
The Saccharomyces cerevisiae sequencing project (the first eukaryotic ...
Hoon S, St Onge RP, Giaever G, Nislow C,
http://dx.doi.org/10.1016/j.tips.2008.07.006
Trends Pharmacol Sci. 2008 Aug 26.
Proband race/ethnicity affects pedigree completion rate in a genetic study of ischemic stroke.
BACKGROUND: A recent meta-analysis suggested that racial/ethnic status is ...
Kissela BM, Brott TG, Brown RD Jr, Silliman SL, Brown WM, Rich SS, Meschia JF,
http://dx.doi.org/10.1016/j.jstrokecerebrovasdis.2008.02.011
J Stroke Cerebrovasc Dis. 2008 Sep;17(5):299-302.
Genetic and epigenetic contributions to human nutrition and health: managing genome-diet interactions.
The Institute of Medicine recently convened a workshop to review the state ...
Stover PJ, Caudill MA,
http://dx.doi.org/10.1016/j.jada.2008.06.430
J Am Diet Assoc. 2008 Sep;108(9):1480-7.
Identifying disease-causal genes using Semantic Web-based representation of integrated genomic and phenomic knowledge.
Most common chronic diseases are caused by the interactions of multiple ...
Gudivada RC, Qu XA, Chen J, Jegga AG, Neumann EK, Aronow BJ,
http://dx.doi.org/10.1016/j.jbi.2008.07.004
J Biomed Inform. 2008 Aug 23.
Assessing TF regulatory relationships of divergently transcribed genes.
Ambiguously located transcription factor (TF) binding sites may introduce ...
Chen L, Cai L, Skogerbo G, Zhao Y, Chen R,
http://dx.doi.org/10.1016/j.ygeno.2008.07.007
Genomics. 2008 Aug 25.
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