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Wednesday 07th January 2009 08:08 AM This Month's Genome Publications

Genomics refers to the study of genes and their function. Genomics leads to an understanding of the molecular mechanisms of disease, including the complex interplay of genetic and environmental factors. Genomics is important in the development of drugs, design of new drugs, vaccines and DNA diagnostics. Genomics-based therapeutics include "traditional" small chemical drugs, protein drugs, and gene therapy. Genomics refers to the large-scale investigation of the structure and function of genes. Genomics aids drug discovery and development, agroscience research, and other fields.

Recent Publications by Featured Genomics Companies:

Pubmed Logo
GlaxoSmithKline Medicines Research Centre Systemic administration of ghrelin increases extracellular dopamine in the shell but not the core subdivision of the nucleus accumbens.
The gut-hormone ghrelin endogenously binds to the ghrelin receptor (GHS-R)...
Department of Biology, Neurosciences CEDD, GlaxoSmithKline Medicines Neurochem Int. 2008 Dec 11.
DOI Direct Link
GlaxoSmithKline Systemic administration of ghrelin increases extracellular dopamine in the shell but not the core subdivision of the nucleus accumbens.
The gut-hormone ghrelin endogenously binds to the ghrelin receptor (GHS-R)...
Department of Biology, Neurosciences CEDD, GlaxoSmithKline Medicines Neurochem Int. 2008 Dec 11.
DOI Direct Link
GlaxoSmithKline Systemic administration of ghrelin increases extracellular dopamine in the shell but not the core subdivision of the nucleus accumbens.
The gut-hormone ghrelin endogenously binds to the ghrelin receptor (GHS-R)...
Department of Biology, Neurosciences CEDD, GlaxoSmithKline Medicines Neurochem Int. 2008 Dec 11.
DOI Direct Link
Pfizer Global Research and Development Determination of a potent urokinase-type plasminogen activator, UK-356,202, in plasma at pg/mL levels using column-switching HPLC and fluorescence detection.
A rapid, sensitive and selective method using column-switching HPLC with...
Department of Pharmacokinetics, Dynamics and Metabolism, Pfizer Global J Chromatogr B Analyt Technol Biomed Life Sci. 2008 Dec 3.
DOI Direct Link
GlaxoSmithKline Mechanism and Management of AKT Inhibitor-Induced Hyperglycemia.
PURPOSE: Insulin-like growth factor-I receptor and phosphoinositide...
Authors' Affiliations: Oncology Biology and Metabolic Diseases, Clin Cancer Res. 2009 Jan 1;15(1):217-25.
DOI Direct Link
GlaxoSmithKline New quinoline NK(3) receptor antagonists with CNS activity.
Lead optimisation starting from the previously reported selective...
Medicinal Chemistry, Neuroscience CEDD GlaxoSmithKline Research & Bioorg Med Chem Lett. 2008 Dec 7.
DOI Direct Link
GlaxoSmithKline Mechanism and Management of AKT Inhibitor-Induced Hyperglycemia.
PURPOSE: Insulin-like growth factor-I receptor and phosphoinositide...
Authors' Affiliations: Oncology Biology and Metabolic Diseases, Clin Cancer Res. 2009 Jan 1;15(1):217-25.
DOI Direct Link

Patents:

USPTO logo
CompanyUS Patent No.Title
Syngenta 7470837 Inbred corn line G1105
Syngenta 7470835 Soybean cultivar
Syngenta 7470831 Genetic method
GlaxoSmithKline 7470782 CASB618 polynucleotides and polypeptides and their use
GlaxoSmithKline 7470782 CASB618 polynucleotides and polypeptides and their use
AstraZeneca 7470678 Diphenylazetidinone derivatives for treating disorders of the lipid metabolism
Waters Corporation 7470057 Differential scanning calorimeter sensor and method
Syngenta 7468453 Production process of gamma-cyhalothrin
Syngenta 7465805 Isoxazoline derivatives and their use as herbicides
AstraZeneca 7465795 Compounds and uses thereof

Latest Genomics Publications:
A HAUSDORFF-BASED NOE ASSIGNMENT ALGORITHM USING PROTEIN BACKBONE DETERMINED FROM RESIDUAL DIPOLAR COUPLINGS AND ROTAMER PATTERNS.
High-throughput structure determination based on solution Nuclear Magnetic ...
Zeng JM, Tripathy C, Zhou P, Donald BR,
Comput Syst Bioinformatics Conf. 2008;2008:169-181.
Sample degradation leads to false-positive copy number variation calls in multiplex real-time polymerase chain reaction assays.
The recent implication of genomic copy number variations (CNVs) in ...
Cukier HN, Pericak-Vance MA, Gilbert JR, Hedges DJ,
http://dx.doi.org/10.1016/j.ab.2008.11.040
Anal Biochem. 2008 Dec 7.
Discovery of transcriptional regulators and signaling pathways in the developing pituitary gland by bioinformatic and genomic approaches.
We report a catalog of the mouse embryonic pituitary gland transcriptome ...
Brinkmeier ML, Davis SW, Carninci P, Macdonald JW, Kawai J, Ghosh D, Hayashizaki Y, Lyons RH, Camper SA,
http://dx.doi.org/10.1016/j.ygeno.2008.11.010
Genomics. 2008 Dec 30.
Cloning of neuropeptide-like precursor 1 in the gray flesh fly and peptide identification and expression.
The neuropeptide-like precursor 1 (NPLP1) was first identified in a ...
Verleyen P, Chen X, Baron S, Preumont A, Hua YJ, Schoofs L, Clynen E,
http://dx.doi.org/10.1016/j.peptides.2008.12.006
Peptides. 2008 Dec 11.
Hepatic overexpression of dominant negative Mlx improves metabolic profile in diabetes-prone C57BL/6J mice.
Mlx and ChREBP form a heterodimer to regulate glucose-mediated gene ...
Iizuka K, Takeda J, Horikawa Y,
http://dx.doi.org/10.1016/j.bbrc.2008.12.100
Biochem Biophys Res Commun. 2008 Dec 30.
A first-generation microsatellite-based genetic linkage map of the Siberian jay (Perisoreus infaustus): insights into avian genome evolution.
ABSTRACT: BACKGROUND: Genomic resources for the majority of free-living ...
Jaari S, Li M, Merila J,
http://dx.doi.org/10.1186/1471-2164-10-1
BMC Genomics. 2009 Jan 3;10(1):1.
Small membrane proteins found by comparative genomics and ribosome binding site models.
The correct annotation of genes encoding the smallest proteins is one of ...
Hemm MR, Paul BJ, Schneider TD, Storz G, Rudd KE,
http://dx.doi.org/10.1111/j.1365-2958.2008.06495.x
Mol Microbiol. 2008 Dec;70(6):1487-501.
Systems biology of innate immunity.
Systems biology is the comprehensive and quantitative analysis of the ...
Zak DE, Aderem A,
http://dx.doi.org/10.1111/j.1600-065X.2008.00721.x
Immunol Rev. 2009 Jan;227(1):264-82.
Emergence and potential of high-throughput and integrative approaches in pathology.
In recent years a major revolution has occurred in the analysis and ...
Frutos R, Viari A, Vachiery N, Boyer F, Lefrancois T, Martinez D,
http://dx.doi.org/10.1196/annals.1428.060
Ann N Y Acad Sci. 2008 Dec;1149:62-5.
Stress-induced intercellular communication remodeling in the rat adrenal medulla.
To understand the mechanisms by which a prolonged exposure to stress ...
Colomer C, Lafont C, Guerineau NC,
http://dx.doi.org/10.1196/annals.1410.040
Ann N Y Acad Sci. 2008 Dec;1148:106-11.
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