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Recent Publications by Evotec UK: |  | |
| An orally bioavailable positive allosteric modulator of the mGlu(4) receptor with efficacy in an animal model of motor dysfunction.
A high-throughput screening campaign identified... | Evotec (UK) Ltd, 114 Milton Park, Abingdon, OX14 4SD, UK. | Bioorg Med Chem Lett. 2010 Jun 25.
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| DNA gyrase (GyrB)/topoisomerase IV (ParE) inhibitors: synthesis and antibacterial activity.
The synthesis and antibacterial activities of three chemotypes of DNA... | Evotec (UK) Ltd, Discovery Services, 114 Milton Park, Abingdon, | Bioorg Med Chem Lett. 2009 Feb 1;19(3):894-9. Epub 2008 Dec 3.
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| mGluR4 positive allosteric modulators with potential for the treatment of Parkinson's disease: WO09010455.
Stimulation of the metabotropic glutamate receptor 4 (mGluR4) represents a... | Evotec (UK) Ltd, 114 Milton Park, Abingdon, OX14 4SA, UK. | Expert Opin Ther Pat. 2010 Mar;20(3):441-5.
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| High-resolution crystal structure of human Mapkap kinase 3 in complex with a high affinity ligand.
The Mapkap kinases 2 and 3 (MK2 and MK3) have been implicated in... | Evotec (UK) Ltd, 114 Milton Park, Abingdon, Oxfordshire OX14 4SA, United | Protein Sci. 2010 Jan;19(1):168-73.
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| Cross-linking of protein crystals as an aid in the generation of binary protein-ligand crystal complexes, exemplified by the human PDE10a-papaverine structure.
Protein crystallography has proven to be an effective method of obtaining... | Evotec UK Ltd, Abingdon, Oxfordshire OX14 4SA, England. | Acta Crystallogr D Biol Crystallogr. 2009 Aug;65(Pt 8):872-4. Epub 2009
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